| Project Id
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BITS025F001480
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| Project Detail
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| Project Title
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Development of surface-decorated lyotropic liquid crystalline drug delivery systems with various lipids/surfactants and optimization of their phase change behavior for superior wound healing application
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| Senior Supervision Team (BITS)
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| Supervisor name and Title
|
Swati Biswas
|
School or Department (or company, if applicable)
|
BITS PILANI, HYDERABAD CAMPUS
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|
|
|
Email ID
|
swati.biswas@hyderabad.bits-pilani.ac.in
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| URL for more info
|
https://universe.bits-pilani.ac.in/hyderabad/biswas/Profile
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| a) Are you currently supervising a BITS or RMIT HDR student?
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YES
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| Please comment how many you are supervising
|
12
|
| b) Have you supervised an offshore candidate before?
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NO
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| If no, what support structures do you have in place?
|
|
| If yes, please elaborate
|
N
|
| Senior Supervision Team (RMIT)
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| Supervisor name and Title
|
Sampa Sarkar
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School or Department (or company, if applicable)
|
STEM
|
|
|
|
Email ID
|
sampa.sarkar@rmit.edu.au
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| URL for more info
|
https://www.rmit.edu.au/contact/staff-contacts/academic-staff/s/sarkar-dr-sampa
|
| a) Are you currently supervising a BITS or RMIT HDR student?
|
YES
|
| Please comment how many you are supervising
|
1
|
| b) Have you supervised an offshore candidate before?
|
YES
|
| If no, what support structures do you have in place?
|
|
| If yes, please elaborate
|
|
| Other Supervisors (BITS)
|
| Supervisor name and Title
|
|
School or Department (or company, if applicable)
|
|
| Phone Number (Optional)
|
|
Email ID
|
|
| URL for more info
|
|
| Other Supervisors (BITS)
|
| Supervisor name and Title
|
Prof. Charlotte Conn
|
School or Department (or company, if applicable)
|
STEM
|
| Phone Number (Optional)
|
+ 61 (0) 3 9925 1787
|
Email ID
|
charlotte.conn@rmit.edu.au
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| URL for more info
|
https://www.rmit.edu.au/contact/staff-contacts/academic-staff/c/conn-professor-charlotte
|
| Field of Research (For Codes)
|
| 20 | Health | 50.00 |
| 31 | Biological sciences | 50.00 |
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| Project Description
|
|
Lyotropic liquid crystals (LLC) are self-assembled structures formed by amphiphilic molecules in water and exhibit various mesophases, such as lamellar, cubic, and hexagonal, depending on the lipid composition and water content. The application of LLCs in wound healing is emerging due to the unique properties of LLCs, which exhibit drug delivery, tissue engineering, bio-adhesion, and moisturization, as well as impart optimum viscoelastic properties for ease of application and spreading. In our work, we aim to develop hydrogel-based LLCs using various lipids and surfactants and study their phase-change behavior amenable for wound application. LLCs will be prepared using monoolein as a lipid, which can self-assemble into cubic, hexagonal, and lamellar phases, and surfactant, including poloxamers, span, tween, lecithin, and any PEGylated surfactants for surface decoration. The microfluidization technique will be used to prepare cubosomes and surface decoration will be executed to impart multifunctionality, including nanozyme incorporation and oxygen-release property by incorporating inorganic manganese oxide nanoparticles.
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| Project Deliverable/Outcomes
|
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The liquid crystalline LLC-metallic hybrid will demonstrate optimal spreading ability on the wound, nanozyme-mediated antibacterial and manganese dioxide-mediated oxygen generation potential suitable for overcoming tissue hypoxia leading to necrosis. The formulation will be evaluated in the diabetic wound healing model.
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| Research Impact Themes
|
| Life sciences | Biotechnology and Bioengineering |
| BETTER HEALTH OUTCOMES | HEALTH INNOVATION AND BIOMEDICAL AND WEARABLE DEVICES |
| ADVANCED MATERIALS, MANUFACTURING AND FABRICATION | NOVEL MATERIALS |
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| Which RMIT Sustainable Development Goal (SDG) does your project align to
|
|
GOOD HEALTH AND WELLBEING
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| Which RMIT Enabling Impact Platform (EIP) does your project align to
|
|
ADVANCED MATERIALS, MANUFACTURING AND FABRICATION
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| Which RMIT Program code will this project sit under?
|
|
DR229 (CHEM AND ENVIRO)
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| Student Capabilities and Qualifications
|
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Candidate should be GPAT/GATE qualified
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Candidate should good for synthesis of Polymers, Characterization of physicochemical Parameter, Determination of anticancer therapeutic effect in the in vitro assay systems, Validation of the in vitro results in the in vivo animal models.
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|
Masters of Pharmacy
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| Preferred discipline of Student
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| Biological Engineering |
| Biological Sciences |
| Biomedical Sciences |
| Pharmaceautical Sciences, Pharmacology |
|